Highway 43 near Lac Ste. Anne was closed in both directions late Friday morning after a crash involving a tanker truck.
Police were called about the scene near the Gunn junction, at Highways 43 and 33 northwest of Edmonton, around 10:20 a.m.
In photos from commuters in the area, flames and heavy smoke were visible.
Mounties said a delivery van and tanker truck crashed, resulting in a fuel oil product fire.
Both drivers were taken by ground ambulance to hospital, although RCMP didn't yet have details on their condition.
Several explosions were visible from the scene.
Detours were put in place for both east-west Highway 43 traffic and north-south Highway 33 traffic. Drivers were told to expect delays as oil clean up could take as long as eight hours.
Photos supplied by Ronda Choiniere